[The effect of pathogenic factors and anti-rheumatic drugs on the proliferation of cultured human fibroblasts].
Identifieur interne : 003F82 ( Main/Exploration ); précédent : 003F81; suivant : 003F83[The effect of pathogenic factors and anti-rheumatic drugs on the proliferation of cultured human fibroblasts].
Auteurs : W H Hauss ; J. Mey ; H. SchulteSource :
- Zeitschrift fur Rheumatologie [ 0340-1855 ]
Descripteurs français
- KwdFr :
- Anti-inflammatoires (pharmacologie), Anti-inflammatoires (usage thérapeutique), Artériosclérose (traitement médicamenteux), Cellules cultivées, Division cellulaire, Endotoxines (pharmacologie), Fibroblastes (), Foetus, Humains, Lipoprotéines LDL (pharmacologie), Rhumatismes (traitement médicamenteux), Staphylococcus.
- MESH :
- pharmacologie : Anti-inflammatoires, Endotoxines, Lipoprotéines LDL.
- traitement médicamenteux : Artériosclérose, Rhumatismes.
- usage thérapeutique : Anti-inflammatoires.
- Cellules cultivées, Division cellulaire, Fibroblastes, Foetus, Humains, Staphylococcus.
English descriptors
- KwdEn :
- Anti-Inflammatory Agents (pharmacology), Anti-Inflammatory Agents (therapeutic use), Arteriosclerosis (drug therapy), Cell Division, Cells, Cultured, Endotoxins (pharmacology), Fetus, Fibroblasts (drug effects), Humans, Lipoproteins, LDL (pharmacology), Rheumatic Diseases (drug therapy), Staphylococcus.
- MESH :
- chemical , pharmacology : Anti-Inflammatory Agents, Endotoxins, Lipoproteins, LDL.
- chemical , therapeutic use : Anti-Inflammatory Agents.
- drug effects : Fibroblasts.
- drug therapy : Arteriosclerosis, Rheumatic Diseases.
- Cell Division, Cells, Cultured, Fetus, Humans, Staphylococcus.
Abstract
1. Staphylolysin and low density lipoprotein (LDL) stimulate the proliferation of cultivated fetal human fibroblasts of the lung. 2. Antirheumatic drugs (prednisolone, acetylsalicylic acid, D-penicillamine and chloroquine) inhibit the proliferation of cultivated fetal human fibroblasts. 3. Antirheumatic drugs (prednisolone, acetylsalicylic acid, D-penicillamine and chloroquine), simultaneously added to the cluture eliminate the acceleration of the proliferation induced by staphylolysine or low density lipoprotein. 4. These results suggest, that in rheumatic diseases either pathogenic factors or antirheumatic drugs stimulate or inhibit, respectively, directly the cells of the connective tissue. Arterial wall cells, being mesenchymal cells, react in similar way on staphylolysine, low density lipoprotein and antirheumatic drugs. The similarity between the rheumatic and the arteriosclerotic process suggest to use antirheumatic drugs in the prevention and therapy of human arteriosclerosis.
PubMed: 224619
Affiliations:
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Le document en format XML
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Mey</name></author><author><name sortKey="Schulte, H" sort="Schulte, H" uniqKey="Schulte H" first="H" last="Schulte">H. Schulte</name></author></analytic><series><title level="j">Zeitschrift fur Rheumatologie</title><idno type="ISSN">0340-1855</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Inflammatory Agents (pharmacology)</term><term>Anti-Inflammatory Agents (therapeutic use)</term><term>Arteriosclerosis (drug therapy)</term><term>Cell Division</term><term>Cells, Cultured</term><term>Endotoxins (pharmacology)</term><term>Fetus</term><term>Fibroblasts (drug effects)</term><term>Humans</term><term>Lipoproteins, LDL (pharmacology)</term><term>Rheumatic Diseases (drug therapy)</term><term>Staphylococcus</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anti-inflammatoires (pharmacologie)</term><term>Anti-inflammatoires (usage thérapeutique)</term><term>Artériosclérose (traitement médicamenteux)</term><term>Cellules cultivées</term><term>Division cellulaire</term><term>Endotoxines (pharmacologie)</term><term>Fibroblastes ()</term><term>Foetus</term><term>Humains</term><term>Lipoprotéines LDL (pharmacologie)</term><term>Rhumatismes (traitement médicamenteux)</term><term>Staphylococcus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Endotoxins</term><term>Lipoproteins, LDL</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Inflammatory Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Fibroblasts</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arteriosclerosis</term><term>Rheumatic Diseases</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anti-inflammatoires</term><term>Endotoxines</term><term>Lipoprotéines LDL</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Artériosclérose</term><term>Rhumatismes</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anti-inflammatoires</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Division</term><term>Cells, Cultured</term><term>Fetus</term><term>Humans</term><term>Staphylococcus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules cultivées</term><term>Division cellulaire</term><term>Fibroblastes</term><term>Foetus</term><term>Humains</term><term>Staphylococcus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">1. Staphylolysin and low density lipoprotein (LDL) stimulate the proliferation of cultivated fetal human fibroblasts of the lung. 2. Antirheumatic drugs (prednisolone, acetylsalicylic acid, D-penicillamine and chloroquine) inhibit the proliferation of cultivated fetal human fibroblasts. 3. Antirheumatic drugs (prednisolone, acetylsalicylic acid, D-penicillamine and chloroquine), simultaneously added to the cluture eliminate the acceleration of the proliferation induced by staphylolysine or low density lipoprotein. 4. These results suggest, that in rheumatic diseases either pathogenic factors or antirheumatic drugs stimulate or inhibit, respectively, directly the cells of the connective tissue. Arterial wall cells, being mesenchymal cells, react in similar way on staphylolysine, low density lipoprotein and antirheumatic drugs. The similarity between the rheumatic and the arteriosclerotic process suggest to use antirheumatic drugs in the prevention and therapy of human arteriosclerosis.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Hauss, W H" sort="Hauss, W H" uniqKey="Hauss W" first="W H" last="Hauss">W H Hauss</name><name sortKey="Mey, J" sort="Mey, J" uniqKey="Mey J" first="J" last="Mey">J. Mey</name><name sortKey="Schulte, H" sort="Schulte, H" uniqKey="Schulte H" first="H" last="Schulte">H. Schulte</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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